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Oncology. 2014;86(3):159-69. doi: 10.1159/000358064. Epub 2014 Mar 12.

Low expression of transforming growth factor beta-1 in cancer tissue predicts a poor prognosis for patients with stage III rectal cancers.

Author information

1
Department of Surgery, Kangbuk Samsung Hospital, Seoul, Republic of Korea.

Abstract

OBJECTIVE:

Transforming growth factor beta (TGF-β) plays an important role in tumorigenesis and metastasis. It works as a tumor suppressor in the normal colon, but acts as a cancer promoter during the late stages of colorectal carcinogenesis. High expression of TGF-β is known to be associated with advanced stages, tumor recurrence and decreased survival of patients. We investigated the expression of TGF-β and its signaling axis molecules and evaluated their prognostic significance in patients with stage III rectal cancers.

METHODS:

Tissues from 201 cases of stage III rectal cancer were subjected to immunohistochemistry for TGF-β1, type II TGF-β receptor, Smad3, Smad4 and Smad7 proteins. The immunoactivities of these molecules were evaluated and the results were compared with clinicopathological variables including patient survival.

RESULTS:

Low expression of TGF-β1 protein was correlated with a decreased disease-free survival in univariate Kaplan-Meier (p = 0.003) and multivariate Cox regression (HR 9.188 and 95% CI 1.256-67.198, p = 0.029) analyses. The loss of Smad4 protein expression was associated with a reduction in disease-free survival in the univariate analysis, but this finding was not significant after the multivariate analysis.

CONCLUSION:

Low expression of TGF-β1 protein is associated with a poor prognosis for patients with stage III rectal cancers.

PMID:
24643220
DOI:
10.1159/000358064
[Indexed for MEDLINE]

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