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PLoS One. 2014 Mar 18;9(3):e91922. doi: 10.1371/journal.pone.0091922. eCollection 2014.

The association between RAD23B Ala249Val polymorphism and cancer susceptibility: evidence from a meta-analysis.

Author information

1
Department of Colorectal Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang, China.
2
Department of Medical Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Suzhou, Jiangsu, China.
3
Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
4
Department of Clinical Pharmacology, Barts and London School of Medicine and Dentistry, London, United Kingdom.

Abstract

BACKGROUND:

A number of studies have investigated associations of genetic variation in RAD23B Ala249Val (rs1805329 C>T) with cancer susceptibility; however, the findings are inconsistent. We performed a meta-analysis to acquire a more precise estimation of the relationship.

METHOD:

We searched literatures from PubMed, Embase and Web of Science. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association between Ala249Val polymorphism and cancer risk.

RESULTS:

A total of 23 studies consisting of 10837 cases and 13971 controls were included in this meta-analysis. Overall, no significant associations were found between RAD23B Ala249Val polymorphism and cancer risk (Val/Val vs. Ala/Ala: OR = 0.97, 95% CI = 0.75-1.25; Ala/Val vs. Ala/Ala: OR = 1.08, 95% CI = 0.96-1.22; recessive model: OR = 0.93, 95% CI = 0.76-1.14 and dominant model: OR = 1.07, 95% CI = 0.94-1.20). We did not find any significant associations in the further stratification analyses by cancer type, ethnicity and source of control.

CONCLUSIONS:

Despite some limitations, this meta-analysis indicates that it is unlikely that the RAD23B 249Val/Val polymorphism may contribute to the individual susceptibility to cancer risk. However, further advanced designed studies with larger sample size and different ethnicities should be conducted to confirm our results.

PMID:
24643114
PMCID:
PMC3958435
DOI:
10.1371/journal.pone.0091922
[Indexed for MEDLINE]
Free PMC Article

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