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Br J Cancer. 2014 Apr 29;110(9):2339-47. doi: 10.1038/bjc.2014.132. Epub 2014 Mar 18.

Cigarette smoking and postmenopausal breast cancer risk in a prospective cohort.

Author information

1
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD 20892, USA.
2
Department of Epidemiology and Biostatistics, University of Maryland School of Public Health, 2234 SPH Building no. 255, College Park, MD 20742, USA.
3
Department of Research and Evaluation, Kaiser Permanente Southern California, 100 South Los Robles Avenue, 2nd Floor, Pasadena, CA 91101, USA.
4
Strategic Issues Research, AARP Research Center, 601 E Street NW, Washington, DC 20049, USA.

Abstract

BACKGROUND:

The relationship between cigarette smoking and breast cancer risk has been inconsistent, potentially due to modification by other factors or confounding.

METHODS:

We examined smoking and breast cancer risk in a prospective cohort of 186 150 female AARP (formerly American Association of Retired Persons) members, ages 50-71 years, who joined the study in 1995-96 by responding to a questionnaire. Through 2006, 7481 breast cancers were diagnosed. Multivariable-adjusted hazard ratios (HRs) were estimated, overall and stratified by breast cancer risk factors, using Cox proportional hazards regression. Multiplicative interactions were evaluated using the likelihood ratio test.

RESULTS:

Increased breast cancer risk was associated with current (HR 1.19, 95% confidence interval (CI) 1.10-1.28) and former (HR 1.07, CI 1.01-1.13) smoking. The current smoking association was stronger among women without (HR 1.24, CI 1.15-1.35) as compared to those with a family history of breast cancer (HR 0.94, CI 0.78-1.13) (P-interaction=0.03). The current smoking association was also stronger among those with later (≥ 15 years: HR 1.52, CI 1.20-1.94) as compared with earlier (≥12 years: HR 1.14, CI 1.03-1.27; 13-14 years: HR 1.18, CI 1.05-1.32) ages at menarche (P-interaction=0.03).

CONCLUSIONS:

Risk was elevated in smokers, particularly in those without a family history or late menarche. Research into smoking's effects on the genome and breast development may clarify these relationships.

PMID:
24642621
PMCID:
PMC4007228
DOI:
10.1038/bjc.2014.132
[Indexed for MEDLINE]
Free PMC Article

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