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Neuropsychopharmacology. 2014 Aug;39(9):2179-90. doi: 10.1038/npp.2014.69. Epub 2014 Mar 19.

Enhancement of memories by systemic administration of insulin-like growth factor II.

Author information

1
1] Center for Neural Science, New York University, New York, NY, USA [2] Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
2
1] Center for Neural Science, New York University, New York, NY, USA [2] Graduate Program in Psychology, University at Albany-SUNY, Albany, NY, USA.
3
Center for Neural Science, New York University, New York, NY, USA.

Abstract

To treat cognitive disorders in humans, new effective therapies that can be easily delivered systemically are needed. Previous studies showed that a bilateral injection of insulin-like growth factor II (IGF-II) into the dorsal hippocampus of rats or mice enhances fear memories and facilitates fear extinction. Here, we report that, in mice, systemic treatments with IGF-II given before training significantly enhance the retention and persistence of several types of working, short-term and long-term memories, including fear conditioning, object recognition, object placement, social recognition, and spatial reference memory. IGF-II-mediated memory enhancement does not alter memory flexibility or the ability for new learning and also occurs when IGF-II treatment is given in concert with memory retrieval. Thus IGF-II may represent a potentially important and effective treatment for enhancing human cognitive and executive functions.

PMID:
24642597
PMCID:
PMC4104337
DOI:
10.1038/npp.2014.69
[Indexed for MEDLINE]
Free PMC Article

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