Format

Send to

Choose Destination
Cell Adh Migr. 2014;8(3):263-7.

Spatial regulation of tumor cell protrusions by RhoC.

Author information

1
Department of Anatomy and Structural Biology; Albert Einstein College of Medicine of Yeshiva University; Bronx, NY USA; Gruss Lipper Biophotonics Center; Albert Einstein College of Medicine of Yeshiva University; Bronx, NY USA.

Abstract

Systemic metastasis is the dissemination of cancer cells from the primary tumor to distant organs and is the primary cause of death in cancer patients. How do cancer cells leave the primary tumor mass? The ability of the tumor cells to form different types of actin-rich protrusions including invasive protrusions (invadopodia) and locomotory protrusions (lamellipodia [2D] or pseudopodia [3D]), facilitate the invasion and dissemination of the tumor cells. Rho-family of p21 small GTPases plays a direct role in regulating the actin dynamics in these intracellular compartments. Recent studies have shown that the signaling molecules including RhoC/p190RhoGEF/p190RhoGAP acts as a "molecular compass" in order to direct the spatial and temporal dynamics of the formation of these invasive and locomotory protrusions leading to efficient invasion.

KEYWORDS:

Invadopodia; RhoA; RhoC; actin cytoskeleton; chemotaxis; cofilin; lamellipodia; p190RhoGAP; p190RhoGEF

PMID:
24642482
PMCID:
PMC4198350
DOI:
10.4161/cam.28405
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center