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Biochim Biophys Acta. 2014 Oct;1843(10):2205-10. doi: 10.1016/j.bbamcr.2014.03.008. Epub 2014 Mar 15.

Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment.

Author information

1
Division of Hematology/Oncology, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, USA; MetroHealth Medical Center, USA. Electronic address: e.f.greenberg@gmail.com.
2
Division of Hematology/Oncology, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, USA. Electronic address: arl18@case.edu.
3
Division of Hematology/Oncology, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, University Hospitals Case Medical Center, USA. Electronic address: cwd@case.edu.

Abstract

The anti-apoptotic protein Bcl-2 is a versatile regulator of cell survival. Its interactions with its own pro-apoptotic family members are widely recognized for their role in promoting the survival of cancer cells. These interactions are thus being targeted for cancer treatment. Less widely recognized is the interaction of Bcl-2 with the inositol 1,4,5-trisphosphate receptor (InsP3R), an InsP3-gated Ca(2+) channel located on the endoplasmic reticulum. The nature of this interaction, the mechanism by which it controls Ca(2+) release from the ER, its role in T-cell development and survival, and the possibility of targeting it as a novel cancer treatment strategy are summarized in this review. This article is part of a Special Issue entitled: Calcium signaling in health and disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau.

KEYWORDS:

Apoptosis; Bcl-2; Cancer; Chronic lymphocytic leukemia; Inositol 1,4,5-trisphosphate receptor; Lymphocyte

PMID:
24642270
PMCID:
PMC4119508
DOI:
10.1016/j.bbamcr.2014.03.008
[Indexed for MEDLINE]
Free PMC Article

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