Format

Send to

Choose Destination
Biol Blood Marrow Transplant. 2014 Jul;20(7):951-9. doi: 10.1016/j.bbmt.2014.03.014. Epub 2014 Mar 15.

Outcomes of hematopoietic cell transplantation for diffuse large B cell lymphoma transformed from follicular lymphoma.

Author information

1
Division of Hematology-Oncology, Stony Brook University Medical Center, Stony Brook, New York. Electronic address: bmwirk@gmail.com.
2
Froedtert Memorial Lutheran Hospital, Milwaukee, Wisconsin.
3
West Virginia University Hospitals, Morgantown, West Virginia.
4
Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.
5
Banner M.D. Anderson Cancer Center, Gilbert, Arizona.
6
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
7
Dana Farber Cancer Institute, Boston, Massachusetts.
8
H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
9
University of Minnesota Medical Center, Minneapolis, Minnesota.
10
Cleveland Clinic, Cleveland, Ohio.
11
New York Medical College, New York Medical College, Valhalla, New York.
12
Barnes Jewish Hospital, St. Louis, Missouri.
13
Massachusetts General Hospital, Boston, Massachusetts.
14
Medical University of South Carolina, Charleston, South Carolina.
15
Henry Ford Hospital Bone Marrow Transplant Program, Detroit, Michigan.
16
South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, Texas.
17
Oregon Health and Science University, Portland, Oregon.
18
Royal Prince Alfred Hospital Institute of Haematology, Camperdown, Australia.
19
All Children's Hospital, St Petersburg, Florida.
20
Fred Hutchinson Cancer Research Center, Seattle, Washington.
21
Shands HealthCare and University of Florida, Gainesville, Florida.
22
Mayo Clinic Rochester, Rochester, Minnesota.
23
Baylor College of Medicine Center for Cell and Gene Therapy, Houston, Texas.
24
Bethesda Health City, Boynton Beach, Florida.
25
Louisiana State University Health Sciences Center, Shreveport, Louisiana.
26
UMass Memorial Medical Center, Worcester, Massachusetts.
27
Vanderbilt University Medical Center, Nashville, Tennessee.
28
Mayo Clinic Arizona and Phoenix Children's Hospital, Phoenix, Arizona.
29
Duke University Medical Center, Durham, North Carolina.
30
Memorial Sloan-Kettering Cancer Center, New York, New York.
31
Academische Ziekenhuis Maastricht, Maastricht, The Netherlands.
32
Addenbrooke's Hospital, Cambridge University, Cambridge, United Kingdom.
33
The Nebraska Medical Center, Omaha, Nebraska.
34
Winship Cancer Institute Emory University, Atlanta, Georgia.
35
Our Lady of Mercy Medical Center, Bronx, New York.
36
Imperial College, Section of Hematology, Division of Experimental Medicine, Department of Medicine, London, United Kingdom.

Abstract

There are limited data on the outcomes of autologous or allogeneic hematopoietic cell transplantation (HCT) in diffuse large B cell lymphoma transformed from follicular lymphoma. We analyzed transplantation outcomes in 141 subjects with biopsy-proven diffuse large B-cell lymphoma transformed from follicular lymphoma reported to the Center for International Blood and Marrow Transplant Research between 1990 and 2009. Two groups were identified: autologous HCT (auto-HCT; n = 108) and allogeneic HCT (allo-HCT; n = 33). Fewer auto-HCTs were done for transformed follicular lymphoma in 2003 to 2009, with a shift favoring allo-HCT. Auto-HCT was associated with a 1-year nonrelapse mortality (NRM) of 8% (95% confidence interval [CI], 4% to 14%), 5-year progression-free survival of 35% (95% CI, 26% to 45%), and 5-year overall survival of 50% (95% CI, 40% to 59%). In contrast, allo-HCT was associated with a 1-year NRM of 41% (95% CI, 23% to 58%), 5-year progression-free survival of 18% (95% CI, 6% to 35%), and 5-year overall survival of 22% (95% CI, 8% to 41%). Auto-HCT for transformed follicular lymphoma achieves sustained remission in a high proportion of subjects. The high NRM of allo-HCT offset any benefit that might be associated with this transplantation modality.

KEYWORDS:

Transformed follicular lymphoma; Transplant

PMID:
24641828
PMCID:
PMC4060436
DOI:
10.1016/j.bbmt.2014.03.014
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center