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Pflugers Arch. 1988 Nov;413(1):105-7.

Enantiomers of clofibric acid analogs have opposite actions on rat skeletal muscle chloride channels.

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Medicinal Chemistry Department, Faculty of Pharmacy, University of Bari, Italy.


The S-(-) isomers of a series of clofibric acid analogs produced only a block of chloride conductance of rat skeletal muscle fibers with increasing concentrations until block was nearly complete. The R-(+) isomers, on the other hand, at low concentrations increased chloride conductance by as much as 9% to 39% and at higher concentrations decreased chloride conductance, but never by more than 27% of the control value. The actions of the enantiomeric pairs to either produce or inhibit myotonic excitability paralleled their ability to block or increase chloride conductance, respectively.

[Indexed for MEDLINE]

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