Format

Send to

Choose Destination
Br J Pharmacol. 2015 Sep;172(18):4588-4590. doi: 10.1111/bph.12617.

GABAB receptors in the bladder and bowel: therapeutic potential for positive allosteric modulators?: Commentary on Kalinichev et al., Br J Pharmacol 171: 995-1006.

Author information

1
Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.
2
Department of Pharmacology & Therapeutics, University College Cork, Cork, Ireland.

Abstract

This article is a Commentary on Kalinichev M, Palea S, Haddouk H, Royer-Urios I, Guilloteau V, Lluel P, Schneider M, Saporito M and Poli S (2014). ADX71441, a novel, potent and selective positive allosteric modulator of the GABAB receptor, shows efficacy in rodent models of overactive bladder. Br J Pharmacol 171: 995-1006. doi: 10.1111/bph.12517.

KEYWORDS:

GABAB receptor; bladder pain syndrome; colon; gastrointestinal; irritable bowel syndrome; motility; positive allosteric modulator; visceral hypersensitivity

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center