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Br J Pharmacol. 2015 Sep;172(18):4588-4590. doi: 10.1111/bph.12617.

GABAB receptors in the bladder and bowel: therapeutic potential for positive allosteric modulators?: Commentary on Kalinichev et al., Br J Pharmacol 171: 995-1006.

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Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland.
Department of Pharmacology & Therapeutics, University College Cork, Cork, Ireland.


This article is a Commentary on Kalinichev M, Palea S, Haddouk H, Royer-Urios I, Guilloteau V, Lluel P, Schneider M, Saporito M and Poli S (2014). ADX71441, a novel, potent and selective positive allosteric modulator of the GABAB receptor, shows efficacy in rodent models of overactive bladder. Br J Pharmacol 171: 995-1006. doi: 10.1111/bph.12517.


GABAB receptor; bladder pain syndrome; colon; gastrointestinal; irritable bowel syndrome; motility; positive allosteric modulator; visceral hypersensitivity

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