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Mult Scler. 2014 Sep;20(10):1331-41. doi: 10.1177/1352458514523498. Epub 2014 Mar 17.

Tracking changes over time in retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in multiple sclerosis.

Author information

1
College of Optometry, Houston, USA.
2
College of Optometry, Houston, USA hcheng@optometry.uh.edu.
3
MS Eye CARE Clinic, University of Houston, USA.

Abstract

BACKGROUND:

Neurodegeneration plays an important role in permanent disability in multiple sclerosis (MS).

OBJECTIVE:

The objective of this paper is to determine whether progressive neurodegeneration occurs in MS eyes without clinically evident inflammation.

METHODS:

Retinal nerve fiver layer thickness (RNFLT) and ganglion cell-inner plexiform layer thickness (GCIPT) were measured using Cirrus optical coherence tomography (OCT) in 133 relapsing-remitting MS (RRMS) patients (149 non-optic neuritis (ON), 97 ON eyes, last ON ≥6 months). Ninety-three patients were scanned at two visits. Percentages of abnormal GCIPT vs RNFLT (<5% of machine norms) in cross-sectional data were compared. Relations between RNFLT/GCIPT and MS duration (cross-sectional) and follow-up time (longitudinal) were assessed.

RESULTS:

GCIPT was abnormal in more eyes than RNFLT (27% vs 16% p = 0.004 in non-ON, 82% vs 72% p = 0.007 in ON). RNFLT and GCIPT decreased with MS duration by -0.49 µm/yr (p = 0.0001) and -0.36 (p = 0.005) for non-ON; -0.52 (p = 0.003) and -0.41 (p = 0.007) for ON. RNFLT and GCIPT decreased with follow-up time by -1.49 µm/yr (p < 0.0001) and -0.53 (p = 0.004) for non-ON, -1.27 (p = 0.002) and -0.49 (p = 0.04) for ON.

CONCLUSIONS:

In RRMS eyes without clinically evident inflammation, progressive loss of RNFLT and GCIPT occurred, supporting the need for neuroprotection in addition to suppression of autoimmune responses and inflammation.

KEYWORDS:

Multiple sclerosis; ganglion cell inner plexiform layer; neurodegeneration; optic neuritis; optical coherence tomography; retinal nerve fiber layer

PMID:
24639478
PMCID:
PMC4306466
DOI:
10.1177/1352458514523498
[Indexed for MEDLINE]
Free PMC Article
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