Format

Send to

Choose Destination
See comment in PubMed Commons below
Cancer Med. 2014 Jun;3(3):453-61. doi: 10.1002/cam4.232. Epub 2014 Mar 18.

The Ca(2+) -activated Cl(-) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis.

Author information

1
Medical Research Center, Affiliated Hospital, Qingdao University, Qingdao, 266555, China; State Key Physiological Discipline, Qingdao University, Qingdao, 266555, China.

Abstract

Since anoctamin 1 ANO1 (TMEM16A) was found to be a molecular component of Ca(2+) -activated Cl(-) channels, its role in tumorigenesis has gained attention at a fast pace. ANO1 overexpression frequently occurs in the cancer tissues along with 11q13 chromosome amplification. Poor prognosis of many types of cancers has been closely correlated with ANO1 gene amplification and protein overexpression. ANO1 is now considered an excellent biomarker for certain cancers. Recent research suggests that it is the channel function of ANO1 that is involved in the tumorigenesis. However, how the overexpression of the functional ANO1 causes malignant transformation of tissues via signaling pathways, for example, MAPK remains to be investigated. Clarification of the reasons in future will avail to make ANO1 as a target for cancer treatment.

KEYWORDS:

ANO1; Ca2+-activated Cl− channel; cancer; cell proliferation; tumorigenesis

PMID:
24639373
PMCID:
PMC4101736
DOI:
10.1002/cam4.232
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center