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J Biomed Opt. 2014 Mar;19(3):35005. doi: 10.1117/1.JBO.19.3.035005.

Diffusion model for ultrasound-modulated light.

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Northeastern University, Department of Electrical and Computer Engineering, 409 Dana Research Center, 360 Huntington Avenue, Boston, Massachusetts 02115bGordon Center for Subsurface Sensing and Imaging Systems (CenSSIS), 360 Huntington Avenue, 302 Stearns.
California Institute of Technology, Department of Electrical Engineering, 1200 E. California Blvd. Mail Code 136-93, Pasadena, California 91125.


Researchers use ultrasound (US) to modulate diffusive light in a highly scattering medium like tissue. This paper analyzes the US-optical interaction in the scattering medium and derives an expression for the US-modulated optical radiance. The diffusion approximation to the radiative transport equation is employed to develop a Green's function for US-modulated light. The predicted modulated fluence and flux are verified using finite-difference time-domain simulations. The Green's function is then utilized to illustrate the modulated reflectance as the US-optical interaction increases in depth. The intent of this paper is to focus on high US frequencies necessary for high-resolution imaging because they are of interest for applications such as phase conjugation.

[Indexed for MEDLINE]

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