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Pediatr Infect Dis J. 2014 Apr;33(4):419-20. doi: 10.1097/INF.0000000000000116.

Antifungal lock therapy with combined 70% ethanol and micafungin in a critically ill infant.

Author information

1
From the *Department of Neonatology; †Department of Biochemical and Clinical Laboratory; and ‡Pharmacy Unit, Bambino Gesù Children's Hospital, Rome, Italy.

Abstract

So-called lock therapy, consisting of high concentrations of antimicrobials instilled into the lumen of the catheter, has been suggested avoid central venous catheter removal during fungal infection. We report a baby who developed catheter-related candidemia. Systemic antifungal treatment did not resolve the candidemia. Lock therapy with 0.3 mL of ethanol 70% and micafungin sodium 5 mg/L was added to the therapy, and blood cultures became sterile.

PMID:
24637514
DOI:
10.1097/INF.0000000000000116
[Indexed for MEDLINE]

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