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J Pediatr. 2014 Jun;164(6):1486-8. doi: 10.1016/j.jpeds.2014.01.057. Epub 2014 Mar 15.

Urinary intestinal fatty acid binding protein predicts necrotizing enterocolitis.

Author information

1
W.F. Connell School of Nursing, Boston College, Chestnut Hill, MA; Department of Nursing, Brigham and Women's Hospital, Boston, MA; Department of Newborn Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address: kgregory1@partners.org.
2
Division of Newborn Medicine, Boston Children's Hospital, Boston, MA.
3
The Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA.
4
The Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.
5
Department of Newborn Medicine, Brigham and Women's Hospital, Boston, MA; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA; The Laboratory of Genital Tract Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA.

Abstract

Necrotizing enterocolitis, characterized by sudden onset and rapid progression, remains the most significant gastrointestinal disorder among premature infants. In seeking a predictive biomarker, we found intestinal fatty acid binding protein, an indicator of enterocyte damage, was substantially increased within three and seven days before the diagnosis of necrotizing enterocolitis.

PMID:
24636854
PMCID:
PMC4120986
DOI:
10.1016/j.jpeds.2014.01.057
[Indexed for MEDLINE]
Free PMC Article

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