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Semin Radiat Oncol. 2014 Apr;24(2):126-31. doi: 10.1016/j.semradonc.2013.11.004.

The role of intraoperative radiation therapy in patients with pancreatic cancer.

Author information

1
Department of Radiation Oncology, Duke University, Durham, NC.
2
Department of Radiation Oncology, Duke University, Durham, NC. Electronic address: Brian.czito@duke.edu.

Abstract

Intraoperative radiation therapy (IORT) techniques allow for the delivery of high doses of radiation therapy while excluding part or all of the nearby dose-limiting sensitive structures. Therefore, the effective radiation dose is increased and local tumor control potentially improved. This is pertinent in the case of pancreatic cancer because local failure rates are as high as 50%-80% in patients with resected and locally advanced disease. Available data in patients receiving IORT after pancreaticoduodenectomy reveal an improvement in local control, though overall survival benefit is unclear. Series of patients with locally advanced pancreatic cancer also suggest pain relief, and in select studies, improved survival associated with the inclusion of IORT. At present, no phase III data clearly supports the use of IORT in the management of pancreatic cancer.

PMID:
24635869
DOI:
10.1016/j.semradonc.2013.11.004
[Indexed for MEDLINE]

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