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J Am Geriatr Soc. 2014 Apr;62(4):679-84. doi: 10.1111/jgs.12742. Epub 2014 Mar 17.

Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer's disease.

Author information

1
Center for Diagnosis and Research on Alzheimer's Disease, Greenfield Park, Quebec, Canada; Department of Internal Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Abstract

OBJECTIVES:

To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI).

DESIGN:

Retrospective chart review.

SETTING:

Community-based memory clinic.

PARTICIPANTS:

Individuals meeting Petersen's MCI criteria (N = 165).

MEASUREMENTS:

Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA-TS, MoCA-MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD.

RESULTS:

One hundred fourteen participants progressed to AD (MCI-AD), and 51 did not (nonconverters; MCI-NC); 90.5% of participants with MCI with a MoCA-TS less than 20/30 and a MoCA-MIS less than 7/15 at baseline converted to AD within the average follow-up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple-domain amnestic MCI had the highest AD conversion rates (73.9%).

CONCLUSION:

Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA-TS and a low newly devised memory index score (MoCA-MIS) are at greater risk of short-term conversion to AD.

KEYWORDS:

Alzheimer; Memory Index Score; Montreal Cognitive Assessment; mild cognitive impairment

PMID:
24635004
DOI:
10.1111/jgs.12742
[Indexed for MEDLINE]

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