Send to

Choose Destination
Learn Mem. 2014 Mar 14;21(4):185-9. doi: 10.1101/lm.033688.113.

The orexin component of fasting triggers memory processes underlying conditioned food selection in the rat.

Author information

Centre de Recherche en Neurosciences de Lyon, CNRS UMR 5292, INSERM U 1028, Université Claude Bernard Lyon1, 69366 Lyon, France.


To test the selectivity of the orexin A (OXA) system in olfactory sensitivity, the present study compared the effects of fasting and of central infusion of OXA on the memory processes underlying odor-malaise association during the conditioned odor aversion (COA) paradigm. Animals implanted with a cannula in the left ventricle received ICV infusion of OXA or artificial cerebrospinal fluid (ACSF) 1 h before COA acquisition. An additional group of intact rats were food-deprived for 24 h before acquisition. Results showed that the increased olfactory sensitivity induced by fasting and by OXA infusion was accompanied by enhanced COA performance. The present results suggest that fasting-induced central OXA release influenced COA learning by increasing not only olfactory sensitivity, but also the memory processes underlying the odor-malaise association.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center