Format

Send to

Choose Destination
See comment in PubMed Commons below
Cardiovasc J Afr. 2014 May-Jun;25(3):100-5. doi: 10.5830/CVJA-2014-011. Epub 2014 Mar 14.

Assessment of the efficacy of Ankaferd blood stopper on the prevention of postoperative pericardial adhesions.

Author information

1
Department of Cardiovascular Surgery, University of Turgut Ozal, Ankara, Turkey.
2
Department of Pathology, University of Turgut Ozal, Ankara, Turkey.

Abstract

OBJECTIVES:

Ankaferd has been used as a blood-stopping agent and it may also have an anti-inflammatory effect. We investigated the efficacy of Ankaferd in preventing postoperative pericardial adhesions in an experimental rabbit model.

METHODS:

Sixteen New Zealand white rabbits were used and categorised into two groups: an Ankaferd and a control group. The Ankaferd group of rabbits was treated with a sponge impregnated with Ankaferd solution, which was applied over the abraded epicardium. A sponge impregnated with 0.9% isotonic NaCl solution was applied to the control group using the same protocol. Scores for adhesion and visibility of coronary vessels were graded by macroscopic examination, and pericardial tissues were analysed microscopically in terms of inflammation and fibrosis.

RESULTS:

In the Ankaferd group, the adhesion scores were significantly higher than in the control group (p = 0.007). When the groups were compared according to the prevalence of fibrosis and degree of inflammation, the Ankaferd group was found to be statistically significantly different from the control group in terms of prevalence of fibrosis (p = 0.028).

CONCLUSIONS:

Topical application of Ankaferd to prevent postoperative pericardial adhesions increased adhesion and fibrosis scores.

PMID:
24633237
PMCID:
PMC4120133
DOI:
10.5830/CVJA-2014-011
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center