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Nat Neurosci. 2014 Apr;17(4):503-5. doi: 10.1038/nn.3674. Epub 2014 Mar 16.

Unbalanced excitability underlies offline reactivation of behaviorally activated neurons.

Author information

1
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
2
Laboratory of Chemistry and Biology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan.
3
Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
4
1] Division of Morphological Neuroscience, Gifu University Graduate School of Medicine, Gifu, Japan. [2] PRESTO, Japan Science and Technology Agency, Saitama, Japan.
5
1] Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan. [2] Center for Information and Neural Networks, Suita City, Osaka, Japan.

Abstract

Hippocampal sharp waves (SWs)/ripples represent the reactivation of neurons involved in recently acquired memory and are crucial for memory consolidation. By labeling active cells with fluorescent protein under the control of an immediate-early gene promoter, we found that neurons that had been activated while mice explored a novel environment were preferentially reactivated during spontaneous SWs in hippocampal slices in vitro. During SWs, the reactivated neurons received strong excitatory synaptic inputs as opposed to a globally tuned network balance between excitation and inhibition.

PMID:
24633127
DOI:
10.1038/nn.3674
[Indexed for MEDLINE]
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