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Nat Commun. 2014 Mar 17;5:3495. doi: 10.1038/ncomms4495.

FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability.

Author information

1
Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
2
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

Abstract

Here, we test the role of FoxP3(+) regulatory T cells (Tregs) in controlling T follicular helper (Tfh) and germinal centre (GC) B-cell responses to influenza. In contrast to the idea that Tregs suppress T-cell responses, we find that Treg depletion severely reduces the Tfh cell response to influenza virus. Furthermore, Treg depletion prevents the accumulation of influenza-specific GCs. These effects are not due to alterations in TGFβ availability or a precursor-progeny relationship between Tregs and Tfh cells, but are instead mediated by increased availability of IL-2, which suppresses the differentiation of Tfh cells and as a consequence, compromises the GC B response. Thus, Tregs promote influenza-specific GC responses by preventing excessive IL-2 signalling, which suppresses Tfh cell differentiation.

PMID:
24633065
PMCID:
PMC4013682
DOI:
10.1038/ncomms4495
[Indexed for MEDLINE]
Free PMC Article

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