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Med J Malaysia. 2013 Oct;68(5):393-6.

Characterisation of rh and other blood group systems amongst the maldivian blood donors.

Author information

1
IGM Hospital, Laboratory Services, Kan'baa aisaarani hingun, Male', 20402, Maldives. m_salym@hotmail.com.
2
IGM Hospital, Laboratory Services, Kan'baa aisaarani hingun, Male', 20402, Maldives.

Abstract

OBJECTIVE:

We here report the first study on the distribution of red cell antigens and phenotype frequencies of various blood group systems in Maldives.

METHOD:

Randomly selected 123 regular blood donors of O group were phenotyped for seven blood group systems by direct tube agglutination and or indirect antiglobulin tests. Blood group systems studied were Rh, Kidd, Duffy, Lewis, Kell, P and MNS system.

RESULTS:

Rh blood grouping showed, 7.3% donors were Rh(D) negative, 92.7% were Rh(D) positive with the predominance of genotype complex of DCe/DCe (39.0%). The incidence of Jk(a+b+) phenotype was the most common in Kidd system. In Duffy system, the incidence of Fy(a+b+) phenotype was 50.4%. Lewis system was predominated by Le(a-b+) phenotype accounting to 80.5% of the donors. In the Kell system only two phenotypes were present, K+k- (5.7%) and k+k+ (94.3%), in the Maldivian blood donors. P system was represented by P1, P2 and P2k phenotypes with an incidence of 28.5%, 70.7% and 0.8% respectively. In the MNS system, MNss and MNSs phenotypes summed up to 48.8% of blood donors.

CONCLUSION:

The detail knowledge of red cell antigen composition and their frequencies in the Maldivian population will be helpful in terms of population genetic perspectives, in establishing a donor data-bank for in-house production of indigenous screening and identification cell panels, and facilitate availability of antigen negative compatible blood for patients with previously identified multiple alloantibodies.

PMID:
24632868
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