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Pediatr Infect Dis J. 2014 Apr;33(4):e99-105. doi: 10.1097/INF.0000000000000237.

Progressive multifocal leukoencephalopathy in pediatric patients: case report and literature review.

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1
From the *Department of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA; †Division of Infectious Diseases, Boston Children's Hospital, Boston, MA; ‡Division of Pediatric Infectious Diseases, David Geffen School of Medicine at UCLA, Mattel Children's Hospital, Los Angeles, CA; §Department of Pathology, Brigham and Women's Hospital; ¶Department of Neurology, Beth Israel Deaconess Medical Center; ‖Department of Neurology, Boston Children's Hospital, Boston, MA; **Department of Pediatrics, Stanford University School of Medicine, Stanford, CA; ††Department of Pathology, Boston Children's Hospital, Boston, MA.

Abstract

Progressive multifocal leukoencephalopathy is a rare, demyelinating disease of the central nervous system caused by JC virus. Fewer than 30 cases have been reported in HIV- and non-infected children. We report the case of a 15-year-old girl with progressive multifocal leukoencephalopathy and AIDS who presented with nystagmus, dysarthria and ataxia. Following combined antiretroviral therapy, she developed immune reconstitution inflammatory syndrome, which proved fatal.

PMID:
24632669
PMCID:
PMC4020507
DOI:
10.1097/INF.0000000000000237
[Indexed for MEDLINE]
Free PMC Article
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