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Curr Opin Neurobiol. 2014 Apr;25:211-20. doi: 10.1016/j.conb.2014.02.013. Epub 2014 Mar 12.

Variability in neural activity and behavior.

Author information

1
Champalimaud Neuroscience Programme, Champalimaud Foundation, Avenida Brasilia, 1400-038 Lisbon, Portugal. Electronic address: alfonso.renart@neuro.fchampalimaud.org.
2
Champalimaud Neuroscience Programme, Champalimaud Foundation, Avenida Brasilia, 1400-038 Lisbon, Portugal. Electronic address: christian.machens@neuro.fchampalimaud.org.

Abstract

Neural activity and behavior in laboratory experiments are surprisingly variable across trials. This variability and its potential causes have been the focus of a spirited debate. Here we review recent research that has shed light on the sources of neural variability and its impact on behavior. We explain how variability may arise from incomplete knowledge about an animal's internal states and its environment. We discuss the problem of incomplete knowledge both from the experimenter's point of view and from the animal's point of view. Both view points are illustrated through several examples from the literature. We furthermore consider both mechanistic and normative models that explain how neural and behavioral variability may be linked. Finally, we review why variability may confer an adaptive advantage to organisms.

PMID:
24632334
DOI:
10.1016/j.conb.2014.02.013
[Indexed for MEDLINE]

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