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Curr Opin Neurobiol. 2014 Aug;27:39-46. doi: 10.1016/j.conb.2014.02.007. Epub 2014 Mar 12.

Role of radial glial cells in cerebral cortex folding.

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Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain. Electronic address:
Institute of Stem Cell Research, German Research Center for Environmental Health, Helmholtz Center Munich, 85764 Neuherberg, Germany; Physiological Genomics, Ludwig Maximilians University, 80336 Munich, Germany. Electronic address:


Radial glial cells play key roles during cerebral cortex development, as primary stem and progenitor cells giving rise-directly or indirectly-to neurons and glia, but also acting as scaffold for the cerebral cortex architecture and migrating neurons. Recent work led to the discovery of novel types of radial glial cells with key roles in gyrification, the folding of the mammalian cerebral cortex in phylogeny and ontogeny. Here we summarize the cellular and molecular basis of this fascinating process allowing the expansion of the mammalian cerebral cortex with all its functional consequences.

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