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Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jun 5;127:225-30. doi: 10.1016/j.saa.2014.02.016. Epub 2014 Feb 22.

Characterization and biological activities of two copper(II) complexes with dipropylenetriamine and diamine as ligands.

Author information

1
Department of Chemistry, Hashemite University, P.O. Box 150459, Zarqa 13115, Jordan. Electronic address: manoaimi@hu.edu.jo.
2
Department of Chemistry, Science College, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
3
Chemistry Department, Faculty of Science, The University of Jordan, Amman 11942, Jordan.
4
Department of Clinical Pharmacy and Therapeutics, Applied Science University, Amman 11931, Jordan.
5
Laboratoire LCM, Faculty of Sciences, University Mohammed 1(ER), Oujda 60000, Morocco.
6
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
7
Biology and Biotechnology Department, AN-Najah National University, P.O. Box 7, Nablus, Palestine.
8
Department of Chemistry, AN-Najah National University, P.O. Box 7, Nablus, Palestine.

Abstract

Two new mixed-ligand copper(II) complexes, [Cu(dipn)(NN)]Br2(1-2) [dipn=dipropylenetriamine, NN=ethylenediamine (en) (1) and propylenediamine (pn) (2)], have been synthesized. These complexes were characterized by spectroscopic and thermal techniques. Crystal structure for 2 shows a distorted trigonal-bipyramidal geometry around Cu(II) ion with one solvate water molecule. Antimicrobial and antiproliferative assays were conducted to evaluate the biological activities of these complexes. The complexes exhibit a promising antimicrobial effect against an array of microbes at 200μg/mL concentration. The antiproliferative assay shows a high potential of these complexes to target Human keratinocyte cell line with IC50 values of 155 and 152μM. The absorption spectrum of 2 in water was modeled by time-dependent density functional theory (TD-DFT).

KEYWORDS:

Biological activity; Cu(II) complexes; Polyamine ligands; Single-crystal XRD

PMID:
24632175
DOI:
10.1016/j.saa.2014.02.016
[Indexed for MEDLINE]
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