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Curr Opin Immunol. 2014 Jun;28:64-70. doi: 10.1016/j.coi.2014.02.001. Epub 2014 Mar 12.

Regulatory constraints in the generation and differentiation of IgE-expressing B cells.

Author information

1
Cardiovascular Research Institute and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.
2
Cardiovascular Research Institute and Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy and Department of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: Chris.Allen@ucsf.edu.

Abstract

B cells expressing antibodies of the immunoglobulin E (IgE) isotype are rare, yet are heavily implicated in the pathogenesis of allergies and asthma. This review discusses recent methodological advances that permit sensitive probing of IgE-expressing (IgE(+)) B cells in vivo and have accordingly clarified the basic behavior and fate of IgE(+) B cells during immune responses in mouse models. IgE antibody secreting plasma cells can arise from extrafollicular foci, germinal centers, and memory B cells. However, compared to B cells expressing other isotypes, IgE(+) B cells are susceptible to multiple additional regulatory constraints that restrict the size of the IgE(+) B cell pool at each stage, coordinately limiting the overall magnitude, affinity, and duration of the IgE antibody response.

PMID:
24632082
PMCID:
PMC4069329
DOI:
10.1016/j.coi.2014.02.001
[Indexed for MEDLINE]
Free PMC Article

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