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Curr Opin Plant Biol. 2014 Apr;18:60-5. doi: 10.1016/j.pbi.2014.02.006. Epub 2014 Mar 15.

Interplay between chromatin and RNA processing.

Author information

1
Clermont Université, Université Blaise Pascal, GReD, BP 10448, F-63000 Clermont-Ferrand, France; CNRS, UMR 6293, GReD, F-63001 Clermont-Ferrand, France; INSERM, UMR 1103, GReD, F-63001 Clermont-Ferrand, France. Electronic address: olivier.mathieu@univ-bpclermont.fr.
2
INRA, UMR 1318, Institut Jean-Pierre Bourgin, RD10, F-78000 Versailles, France; AgroParisTech, Institut Jean-Pierre Bourgin, RD10, F-78000 Versailles, France. Electronic address: Nicolas.Bouche@versailles.inra.fr.

Abstract

The processing of pre-mRNAs, including the selection of polyadenylation sites, is influenced by the surrounding chromatin context. We review here recent studies in Arabidopsis thaliana highlighting the intricate and reciprocal interplay between chromatin state and RNA processing. The studies have revealed that transcription can be influenced by the presence, in gene introns, of combination of epigenetic marks typical of heterochromatin. New factors binding to these marks have been identified and shown to play key roles in controlling the use of polyadenylation sites and processing of functional mRNAs. Concomitantly, several proteins of both the splicing and the polyadenylation machineries are also emerging as regulators of DNA methylation patterns and chromatin silencing.

PMID:
24631845
DOI:
10.1016/j.pbi.2014.02.006
[Indexed for MEDLINE]

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