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Neurobiol Learn Mem. 2014 May;111:35-40. doi: 10.1016/j.nlm.2014.03.003. Epub 2014 Mar 13.

Role of glutamate receptors of central and basolateral amygdala nuclei on retrieval and reconsolidation of taste aversive memory.

Author information

1
Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades, Coordinación de Investigación del Instituto Mexicano del Seguro Social, México, DF, Mexico.
2
División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, AP 70-253, México, DF 04510, Mexico.
3
División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, AP 70-253, México, DF 04510, Mexico; Departamento de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Xochimilco, México, DF, Mexico.
4
División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, AP 70-253, México, DF 04510, Mexico. Electronic address: fbermude@ifc.unam.mx.

Abstract

There are a number of experiments showing an important involvement of amygdala N-methyl-d-aspartate (NMDA) glutamate receptors on consolidation of conditioned taste aversion (CTA) memory. Interestingly, recent evidence has shown that α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors are particularly involved in CTA retrieval. Memory reconsolidation has been proposed as a destabilization and re-stabilization process induced by memory reactivation. We have recently suggested that reconsolidation could be enabled in the absence of retrieval. Hence, we decided to analyze the participation of AMPA and NMDA receptors of the central (CeA) and basolateral amygdala (BLA) in CTA memory retrieval and reconsolidation. To do so, we tested whether administrations of an AMPA receptor blocker (NBQX) or an NMDA receptor blocker (APV) 15 min before a second acquisition trial could have effects on taste aversion. We found that administration of NBQX in the BLA blocked retrieval, whereas APV blocked reconsolidation in the BLA, and consolidation in the CeA. When we administered both NBQX and APV into the BLA before the second acquisition trial, results showed impairment of both retrieval and reconsolidation. These results further support the idea that reconsolidation is independent of retrieval, since retrieval blockade in the BLA did not impair memory reconsolidation. These results suggest that glutamate receptors have different participation on retrieval and reconsolidation of CTA and further support the hypothesis that these two processes could be independent.

KEYWORDS:

Amygdala; Glutamate; Reconsolidation; Retrieval; Taste recognition

PMID:
24631645
DOI:
10.1016/j.nlm.2014.03.003
[Indexed for MEDLINE]

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