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Appetite. 2014 Jun;77:72-6. doi: 10.1016/j.appet.2014.02.021. Epub 2014 Mar 13.

Dose-response effect of a novel functional fibre, PolyGlycopleX(®), PGX(®), on satiety.

Author information

1
School of Public Health, Faculty of Health Sciences, Curtin University of Technology, GPO Box U1987, Perth, WA 6845, Australia. Electronic address: v.solah@curtin.edu.au.
2
Boden Institute of Obesity, Nutrition and Exercise and the School of Molecular Bioscience, University of Sydney, Sydney, NSW, 2006, Australia.
3
Factors Group R and D, Burnaby, BC, V3N 4S9, Canada.
4
Canadian Centre for Functional Medicine, Coquitlam, BC, V3K 6Y2, Canada.
5
Canadian Centre for Functional Medicine, Coquitlam, BC, V3K 6Y2, Canada; Food, Nutrition and Health Program, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
6
School of Public Health, Faculty of Health Sciences, Curtin University of Technology, GPO Box U1987, Perth, WA 6845, Australia; Food, Nutrition and Health Program, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada; InovoBiologic Inc., Calgary, AB, Y2N 4Y7, Canada.

Abstract

The objective of this research was to determine the dose-response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX(®) (PGX(®)), [(α-D-glucurono-α-manno-β-D-manno-β-D-gluco), (α-Lgulurono-β-D mannurono), (β-D-gluco-β-D-mannan)] on satiety, and to gain insight into the underlying mechanisms that lead to appetite inhibition. Healthy subjects (n = 10), aged between 20.3 and 29.2 years, consumed PGX(®), in granular form at 2.5, 5.0 and 7.5 g, and a 5g inulin control, with a standard breakfast. The PGX(®) doses of 2.5 and 7.5 g mixed with water at the start of breakfast increased satiety (iAUC of 140.0 and 157.7, P = 0.025 and 0.001, respectively) compared to the control. The most effective dose (7.5g) was palatable and corresponded to a 34% increase in fullness, measured using a visual analogue scale and incremental area under the curve, and resulted in a delayed postprandial glycaemic response when compared with the control.

KEYWORDS:

Dose; Fibre; Satiety

PMID:
24631638
DOI:
10.1016/j.appet.2014.02.021
[Indexed for MEDLINE]
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