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Gastroenterology. 2014 May;146(6):1470-6. doi: 10.1053/j.gastro.2014.03.001. Epub 2014 Mar 11.

The intestinal metabolome: an intersection between microbiota and host.

Author information

1
Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado.
2
Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts.
3
Departments of Pharmacology, Chemistry, and Biochemistry, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California.
4
Department of Plant Science, Pennsylvania State University, University Park, Pennsylvania.
5
Department of Food Science, Pennsylvania State University, University Park, Pennsylvania.
6
Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado; BioFrontiers Institute, University of Colorado at Boulder, Boulder, Colorado; Howard Hughes Medical Institute, Boulder, Colorado. Electronic address: rob.knight@colorado.edu.

Abstract

Recent advances that allow us to collect more data on DNA sequences and metabolites have increased our understanding of connections between the intestinal microbiota and metabolites at a whole-systems level. We can also now better study the effects of specific microbes on specific metabolites. Here, we review how the microbiota determines levels of specific metabolites, how the metabolite profile develops in infants, and prospects for assessing a person's physiological state based on their microbes and/or metabolites. Although data acquisition technologies have improved, the computational challenges in integrating data from multiple levels remain formidable; developments in this area will significantly improve our ability to interpret current and future data sets.

KEYWORDS:

Bacteria; Data Analysis; Metabolomics; Systems Biology

PMID:
24631493
PMCID:
PMC4102302
DOI:
10.1053/j.gastro.2014.03.001
[Indexed for MEDLINE]
Free PMC Article
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