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Semin Cell Dev Biol. 2014 Apr;28:12-21. doi: 10.1016/j.semcdb.2014.03.003. Epub 2014 Mar 12.

From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease.

Author information

1
Departments of Medicine and Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address: bhuminder.singh@vanderbilt.edu.
2
Departments of Medicine and Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Veteran Affairs Medical Center, Nashville, TN 37232, USA. Electronic address: robert.coffey@vanderbilt.edu.

Abstract

Since its discovery in 1978 and cloning in 1984, transforming growth factor-alpha (TGF-α, TGFA) has been one of the most extensively studied EGF receptor (EGFR) ligands. In this review, we provide a historical perspective on TGFA-related studies, highlighting what we consider important advances related to its function in normal and disease states.

KEYWORDS:

Autocrine singaling; Basolateral trafficking; EGFR, epidermal growth factor receptor; Ménétrier's disease; Polarized epithelial cells; TGFA, transforming growth factor alpha

PMID:
24631356
PMCID:
PMC4105142
DOI:
10.1016/j.semcdb.2014.03.003
[Indexed for MEDLINE]
Free PMC Article
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