Send to

Choose Destination
Clin Immunol Immunopathol. 1989 Jan;50(1 Pt 2):S140-8.

Combined immunodeficiency with abnormal expression of MHC class II genes.

Author information

Inserm U 132, Département de Pédiatrie, Hôpital des Enfants Malades, Paris, France.


The MHC class II CID represents an example of immunodeficiency in which the defect in expression of membrane glycoproteins leads to abnormal cell to cell interactions and thus to abnormal immune responses. It represents an interesting model which confirms the importance of MHC molecules in all immune responses to foreign antigens. It also underlines the complexity of regulatory mechanism which control the expression of MHC class II genes. To elucidate these mechanisms, it is essential to identify and characterize the genes involved in control of MHC class II expression.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center