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Clin Biochem. 2014 May;47(7-8):673-5. doi: 10.1016/j.clinbiochem.2014.02.023. Epub 2014 Mar 11.

Gestational thyroid reference intervals in antibody-negative Chinese women.

Author information

1
Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou 310006, China. Electronic address: merrytwinsister@163.com.
2
Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou 310006, China. Electronic address: xiezhenwei315@163.com.
3
Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou 310006, China. Electronic address: lusm@zju.edu.cn.
4
Department of Laboratory Medicine, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore. Electronic address: tarchoon@gmail.com.
5
Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road #2, Hangzhou 310006, China. Electronic address: mijvbobo@126.com.

Abstract

OBJECTIVES:

The aim of this study is to establish gestation-specific reference intervals (GRIs) for thyroid function assays in pregnant Chinese women with ARCHITECT and compare them to other GRI studies.

DESIGN AND METHOD:

Thyroid antibody negative pregnant Chinese women were enrolled and followed to establish GRIs for thyroid function by use of the Abbott ARCHITECT i2000SR analyzer (N=1409). Samples from 360 non-pregnant Chinese women served as controls.

RESULTS:

GRIs of thyroid-stimulating hormone, free thyroxine and free triiodothyronine for first trimester pregnancies were 0.16-3.78mIU/L, 10.9-17.7pmol/L and 2.9-5.0pmol/L, respectively. GRIs for second trimester pregnancies were 0.34-3.51mIU/L, 9.3-15.2pmol/L and 2.9-4.6pmol/L. GRIs for third trimester pregnancies were 0.34-4.32mIU/L, 7.9-14.1pmol/L and 2.9-4.5pmol/L.

CONCLUSIONS:

Our thyroid GRIs were different from those in other Chinese studies generated on other analyzers, but were similar to a Swiss study using the same analyzer. These data should prove useful for the interpretation of thyroid function assays among pregnant women measured on the Abbott analyzer.

KEYWORDS:

Pregnancy; Reference interval; Thyroid function assay

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