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Cell Metab. 2014 May 6;19(5):741-756. doi: 10.1016/j.cmet.2014.02.007. Epub 2014 Mar 13.

Central neural regulation of brown adipose tissue thermogenesis and energy expenditure.

Author information

1
Department of Neurological Surgery Oregon Health & Science University Portland, OR, 97239 USA.
#
Contributed equally

Abstract

Thermogenesis, the production of heat energy, is the specific, neurally regulated, metabolic function of brown adipose tissue (BAT) and contributes to the maintenance of body temperature during cold exposure and to the elevated core temperature during several behavioral states, including wakefulness, the acute phase response (fever), and stress. BAT energy expenditure requires metabolic fuel availability and contributes to energy balance. This review summarizes the functional organization and neurochemical influences within the CNS networks governing the level of BAT sympathetic nerve activity to produce the thermoregulatory and metabolically driven alterations in BAT thermogenesis and energy expenditure that contribute to overall energy homeostasis.

PMID:
24630813
PMCID:
PMC4016184
DOI:
10.1016/j.cmet.2014.02.007
[Indexed for MEDLINE]
Free PMC Article

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