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J Diabetes Complications. 2014 Jul-Aug;28(4):482-7. doi: 10.1016/j.jdiacomp.2014.02.008. Epub 2014 Feb 26.

Prevalence and associations of diabetic retinopathy in a large cohort of prediabetic subjects: the Gutenberg Health Study.

Author information

1
Department of Ophthalmology, University Medical Centre Mainz, Mainz/Germany.
2
NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London/UK.
3
Department of Medicine 2, University Medical Center Mainz, Germany; Center for Thrombosis and Hemostasis, University Medical Center Mainz, Germany; German Center for Cardiovascular Research (DZHK), University Medical Center Mainz, Germany.
4
Department of Medicine 2, University Medical Center Mainz, Germany.
5
Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Centre Mainz, Mainz/Germany.

Abstract

AIMS:

To evaluate the prevalence of diabetic retinopathy/maculopathy (DR/DMac) and its associations with cardiovascular risk factors (CRF) in participants with prediabetes (PwPD) in a large European cohort within the population-based Gutenberg Health Study (GHS).

METHODS:

The study was based on a sub-cohort of the GHS (n=5,000, age: 35-74 y). Prediabetes was diagnosed according to HbA1c levels (5.7-6.4%). DR/DMac was graded from fundus photographs. Blood samples and comprehensive questionnaires served for evaluation of laboratory results and CRF.

RESULTS:

The prevalence of prediabetes was 22.4%, and of DR/DMac 8.1%/0.2%, respectively. The majority of participants had mild DR (7.2%). A percentage of 0.5 of PwPD presented with moderate and 0.3% with severe non-proliferative disease. None of the subjects had proliferative DR. No independent association was found between any of the analyzed CRF [hypertension, smoking, (family) history of myocardial infarction, congestive heart failure, coronary heart disease, stroke, obesity, dyslipidemia, chronic obstructive pulmonary disease, peripheral artery disease and chronic kidney disease] and DR.

CONCLUSIONS:

Although prevalences of prediabetes and DR in this Caucasian cohort are considerable, retinopathy findings are mainly mild, and no association was found for DR/DMac and CRF.

KEYWORDS:

Cardiovascular risk factors; Diabetic maculopathy; Diabetic retinopathy; Prediabetes; Screening

PMID:
24630763
DOI:
10.1016/j.jdiacomp.2014.02.008
[Indexed for MEDLINE]

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