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Bioorg Med Chem Lett. 2014 Apr 1;24(7):1719-23. doi: 10.1016/j.bmcl.2014.02.044. Epub 2014 Feb 27.

Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents.

Author information

1
Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India.
2
Parasitology Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India; Academy of Scientific and Innovative Research, New Delhi, India.
3
Parasitology Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India.
4
Microbiology Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India; Academy of Scientific and Innovative Research, New Delhi, India.
5
Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India; Academy of Scientific and Innovative Research, New Delhi, India. Electronic address: batra_san@yahoo.co.uk.

Abstract

Synthesis and bioevaluation of new diaryl ether hybridized quinoline derivatives as antiplasmodial, antibacterial and antifungal agents is reported. It was encouraging to discover that several compounds displayed 2-3 folds better efficacy than chloroquine in chloroquine-resistant K1 strain of Plasmodium falciparum. Further, a few members of the library displayed good antibacterial efficacy against gram positive strains of bacteria but none of the compounds displayed any significant antifungal activity.

KEYWORDS:

Antibacterial; Diaryl ether; Hybrid; Malaria; Quinoline

PMID:
24630564
DOI:
10.1016/j.bmcl.2014.02.044
[Indexed for MEDLINE]
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