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Leuk Res. 2014 Apr;38(4):490-5. doi: 10.1016/j.leukres.2014.01.014. Epub 2014 Feb 4.

Chronic kidney disease in patients with the Philadelphia-negative chronic myeloproliferative neoplasms.

Author information

1
Department of Hematology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark. Electronic address: axchristensen@gmail.com.
2
Quantitative Clinical Pharmacology, Novo Nordisk A/S, Søborg, Denmark.
3
Department of Hematology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark.

Abstract

BACKGROUND:

The progression of kidney function and frequency of chronic kidney disease (CKD) in patients with the Philadelphia-negative myeloproliferative neoplasms (MPN) is unknown, although CKD is linked to increased mortality.

METHODS:

This longitudinal retrospective study evaluates the estimated glomerular filtration rate (eGFR) in 143 MPN patients over a period of 9 years.

RESULTS:

29% of patients had CKD stage 3 or 4 at time of diagnosis. 20% of patients had a rapid annual loss of eGFR (>3mL/min/1.73m(2)) and eGFR was negatively correlated to monocyte and neutrophil counts.

CONCLUSION:

Kidney impairment might contribute to the increased mortality observed in MPN patients.

KEYWORDS:

Chronic inflammation; Chronic kidney disease; Essential thrombocythemia; Hydroxyurea; Myelofibrosis; Myeloproliferative neoplasms; Polycythemia vera

PMID:
24630365
DOI:
10.1016/j.leukres.2014.01.014
[Indexed for MEDLINE]
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