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[Association of GSTM1 and GSTT1 polymorphisms with noise-induced hearing loss: a meta-analysis].

[Article in Chinese]

Author information

1
Hefei Prevention and Treatment Center for Occupational Diseases, Hefei 230001, China.
2
E-mail: ranwang2005@126.com.

Abstract

OBJECTIVE:

To evaluate the association of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) polymorphisms with noise-induced hearing loss.

METHODS:

The Cochrane library, PubMed, OVID, EMBASE, Springer, Wanfang Data, VIP, CNKI, and CBM were searched to collect case-control studies on GSTM1 or GSTT1 polymorphism and noise-induced hearing loss. The articles meeting the inclusion criteria were reviewed systematically, and the reported data were aggregated using Revman 5.0.

RESULTS:

Five studies were included in the meta-analysis. The meta-analysis and subgroup analysis showed that the persons with GSTM1 null genotype had an increased risk of noise-induced hearing loss compared with those with GSTM1 wild genotype (OR = 1.37, 95%CI: 1.13∼1.66); in the Chinese population, the risk of noise-induced hearing loss was higher in persons with GSTM1 null genotype than in those with GSTM1 wild genotype (OR = 1.5, 95%CI: 1.2∼1.86); there was no significant difference in the risk of noise-induced hearing loss between persons with GSTT1 null and wild genotypes.

CONCLUSION:

GSTM1 polymorphism is related to noise-induced hearing loss, but GSTT1 polymorphism is unrelated to this condition.

PMID:
24630014
[Indexed for MEDLINE]
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