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Food Chem. 2014 Aug 1;156:408-15. doi: 10.1016/j.foodchem.2014.01.078. Epub 2014 Feb 6.

Evaluation of the antioxidant and anti-osteoporosis activities of chemical constituents of the fruits of Prunus mume.

Author information

1
College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
2
Department of Food and Nutrition, Hannam University, Daejeon 305-811, Republic of Korea.
3
Department of Food and Nutrition, Hannam University, Daejeon 305-811, Republic of Korea. Electronic address: haedong@hnu.kr.
4
College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea. Electronic address: yhk@cnu.ac.kr.

Abstract

The present study investigated the antioxidant and anti-osteoporosis activities of phytochemicals in the fruits of Prunus mume. From the methanol extract, three new acylated sucroses, mumeoses P-R (1-3), were isolated together with 20 known compounds (4-23). Compounds 1-3 showed potent peroxyl radical-scavenging activities and 12-19 showed both potent peroxyl radical-scavenging and reducing activities. The anti-osteoporosis activity was evaluated using murine pre-osteoblastic MC3T3-E1 cells and pre-osteoclastic RAW 264.7 cells. Compounds 2 and 3 (cis-trans isomers), 5, 7, 8, and 10 significantly stimulated the differentiation of pre-osteoblastic MC3T3-E1 cells to increase collagen synthesis or mineralization functions of osteoblasts, while compounds 5, 6, 9, 10, 12, 14-16, 18, 20, and 22 significantly suppressed tartrate-resistant acid phosphatase activity in receptor activator of nuclear factor-κB ligand-induced osteoclastic RAW 264.7 cells. These results indicated that the fruits of P. mume are an excellent source of antioxidant and anti-osteoporosis phytochemicals.

KEYWORDS:

Acylated sucrose; Anti-osteoporosis activity; Antioxidant activity; Prunus mume; Rosaceae

PMID:
24629988
DOI:
10.1016/j.foodchem.2014.01.078
[Indexed for MEDLINE]

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