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Food Chem. 2014 Aug 1;156:87-93. doi: 10.1016/j.foodchem.2014.01.098. Epub 2014 Feb 6.

Strawberry intake increases blood fluid, erythrocyte and mononuclear cell defenses against oxidative challenge.

Author information

1
Dipartimento di Science Cliniche Specialistiche ed Odontostomatologiche, Facoltà di Medicina, Università Politecnica delle Marche, Ancona, Italy.
2
Grupo de Investigación en Polifenoles (GIP-USAL), Faculty of Pharmacy, Salamanca University, Campus Miguel de Unamuno, E-37007 Salamanca, Spain.
3
Laboratory of Torrette-Umberto I Regional Hospital, Ancona, Italy.
4
Dipartimento di Scienze Biomediche e Sanità Pubblica, Facoltà di Medicina, Università Politecnica delle Marche, Ancona, Italy.
5
Instituto de Nutricion y Tecnologia de Alimentos (INYTA), Department of Physiology, Universidad de Granada, Granada, Spain.
6
Dipartimento di Scienze Agrarie, Alimentari ed Ambientali (D3A), Università Politecnica delle Marche, Ancona, Italy.
7
Dipartimento di Science Cliniche Specialistiche ed Odontostomatologiche, Facoltà di Medicina, Università Politecnica delle Marche, Ancona, Italy. Electronic address: m.a.battino@univpm.it.

Abstract

The health promoting effects of a regular consumption of strawberries deserve attention, and a direct or indirect antioxidant role of strawberry bioactive compounds is among the most probable mechanisms underlying their beneficial properties. In the present study, we evaluated the overall effects of a 2-week daily consumption of strawberries on plasma antioxidant status, membrane lipid susceptibility to ex vivo-induced oxidation, and erythrocyte and mononuclear cell resistance to oxidative damage in apparently healthy volunteers. After strawberry intake, a moderate increase in fasting plasma antioxidant capacity and vitamin C was observed, together with a significant increase in the lag phase preceding plasma lipid oxidation. A significantly enhanced resistance to oxidative hemolysis was confirmed in red blood cells, while no significant changes were found in the extent of their membrane lipid peroxidation. For the first time, increased intake of strawberries for only 2weeks was shown to be sufficient to attenuate mononuclear cell mortality after ex vivo exposure to a single acuteoxidative challenge, but the analysis of DNA oxidative damage gave conflicting results. These findings suggest that a regular consumption of strawberries may enhance body defences against oxidative challenges.

KEYWORDS:

Antihaemolytic effects; DNA damage; Human study; Mononuclear cell mortality; Plasma antioxidant status; Strawberry

PMID:
24629942
DOI:
10.1016/j.foodchem.2014.01.098
[Indexed for MEDLINE]

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