Format

Send to

Choose Destination
Cell Host Microbe. 2014 Mar 12;15(3):260-5. doi: 10.1016/j.chom.2014.01.002.

Viruses for tumor therapy.

Author information

1
Center for Cancer Therapeutics, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
2
Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA. Electronic address: grantmcf@ufl.edu.

Abstract

Oncolytic virotherapy exploits live viruses with selective tropism for cancerous cells and tissues to treat cancer. As discussed here, the field has progressed considerably as a result of both the successes and failures of previous and on-going clinical trials for various cancers. These studies indicate that oncolytic viruses are remarkably safe and more efficacious when virus replication stimulates sustained antitumor immune responses. In the future, virotherapy should be combined with immunomodulatory reagents that target immune tolerance to established cancers.

PMID:
24629333
PMCID:
PMC3963258
DOI:
10.1016/j.chom.2014.01.002
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center