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Biophys J. 1988 Aug;54(2):309-20.

The use of dwell time cross-correlation functions to study single-ion channel gating kinetics.

Author information

1
Department of Mathematics, University of Nottingham, United Kingdom.

Abstract

The derivation of cross-correlation functions from single-channel dwell (open and closed) times is described. Simulation of single-channel data for simple gating models, alongside theoretical treatment, is used to demonstrate the relationship of cross-correlation functions to underlying gating mechanisms. It is shown that time irreversibility of gating kinetics may be revealed in cross-correlation functions. Application of cross-correlation function analysis to data derived from the locust muscle glutamate receptor-channel provides evidence for multiple gateway states and time reversibility of gating. A model for the gating of this channel is used to show the effect of omission of brief channel events on cross-correlation functions.

PMID:
2462924
PMCID:
PMC1330298
DOI:
10.1016/S0006-3495(88)82961-8
[Indexed for MEDLINE]
Free PMC Article

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