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Diabet Med. 2014 Aug;31(8):941-5. doi: 10.1111/dme.12434. Epub 2014 Apr 9.

Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and type 2 diabetes: Action LADA 9 [corrected].

Author information

  • 1Sydvestjysk Hospital, Esbjerg, Denmark; Odense University Hospital, Odense, Denmark.

Erratum in

  • Diabet Med. 2014 Nov;31(11):1477.



To explore insulin sensitivity and insulin secretion in people with latent autoimmune diabetes in adulthood (LADA) compared with that in people with type 2 diabetes.


A total of 12 people with LADA, defined as glutamic acid decarboxylase (GAD) antibody positivity and > 1 year of insulin independency (group A) were age-matched pairwise to people with type 2 diabetes (group B) and to six people with type 2 diabetes of similar age and BMI (group C). β-Cell function (first-phase insulin secretion and assessment of insulin pulsatility), insulin sensitivity (hyperinsulinemic-euglycemic clamp) and metabolic response during a mixed meal were studied.


Both first-phase insulin secretion and insulin release during the meal were greater (P = 0.05 and P = 0.009, respectively) in type 2 diabetes as compared with LADA; these differences were lost on adjustment for BMI (group C) and could be explained by BMI alone in a multivariate analysis. Neither insulin pulsatility, incretin secretion nor insulin sensitivity differed among the groups.


We found no evidence that LADA and type 2 diabetes were distinct disease entities beyond the differences explained by BMI.

[PubMed - indexed for MEDLINE]
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