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J Vet Intern Med. 2014 May-Jun;28(3):925-33. doi: 10.1111/jvim.12341. Epub 2014 Mar 14.

Efficacy of omeprazole powder paste or enteric-coated formulation in healing of gastric ulcers in horses.

Author information

1
Equine Department, Vetsuisse Faculty, Clinic for Equine Internal Medicine, University of Zurich, Zurich, Switzerland.

Abstract

BACKGROUND:

GastroGard, an omeprazole powder paste formulation, is considered the standard treatment for gastric ulcers in horses and is highly effective. Gastrozol, an enteric-coated omeprazole formulation for horses, has recently become available, but efficacy data are controversial and sparse.

OBJECTIVES:

To investigate the efficacy of GastroGard and Gastrozol at labeled doses (4 and 1 mg of omeprazole per kg bwt, respectively, PO q24h) in healing of gastric ulcers.

ANIMALS:

40 horses; 9.5 ± 4.6 years; 491 ± 135 kg.

METHODS:

Prospective, randomized, blinded study. Horses with an ulcer score ≥1 (Equine Gastric Ulcer Council) were randomly divided into 2 groups and treated for 2 weeks each with GastroGard followed by Gastrozol (A) or vice versa (B). After 2 and 4 weeks, scoring was repeated and compared with baseline. Plasma omeprazole concentrations were measured on the first day of treatment after administration of GastroGard (n = 5) or Gastrozol (n = 5).

RESULTS:

Compared with baseline (squamous score (A) 1.65 ± 0.11, (B) 1.98 ± 0.11), ulcer scores at 2 weeks ((A) 0.89 ± 0.11, (B) 1.01 ± 0.11) and 4 weeks ((A) 1.10 ± 0.12, (B) 0.80 ± 0.12) had significantly decreased in both groups (P < .001), independent of treatment (P = .7). Plasma omeprazole concentrations were significantly higher after GastroGard compared with Gastrozol administration (AUCGG = 2856 (1405-4576) ng/mL × h, AUCGZ = 604 (430-1609) ng/mL × h; P = .03). The bioavailability for Gastrozol was 1.26 (95% CI 0.56-2.81) times higher than for GastroGard.

CONCLUSIONS AND CLINICAL IMPORTANCE:

Both Gastrozol and GastroGard, combined with appropriate environmental changes, promote healing of gastric ulcers in horses. However, despite enteric coating of Gastrozol, plasma omeprazole concentrations after single labeled doses were significantly higher with GastroGard.

KEYWORDS:

EGUS; GastroGard; Gastroenterology; Gastrozol

PMID:
24628650
PMCID:
PMC4895457
DOI:
10.1111/jvim.12341
[Indexed for MEDLINE]
Free PMC Article

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