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Br J Haematol. 2014 Jun;165(6):836-41. doi: 10.1111/bjh.12834. Epub 2014 Mar 15.

ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children.

Author information

1
Department of Paediatric Haematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.

Abstract

We identified ATF7IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B-ALL) and showed that B-ALL with ATF7IP/PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B-ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup.

KEYWORDS:

ATF7IP; PDGFRB; Ph-like; acute lymphoblastic leukaemia; screening

PMID:
24628626
DOI:
10.1111/bjh.12834
[Indexed for MEDLINE]

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