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J Org Chem. 2014 Apr 4;79(7):3267-71. doi: 10.1021/jo5003032. Epub 2014 Mar 26.

Palladium-catalyzed decarboxylative trifluoroethylation of aryl alkynyl carboxylic acids.

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1
Department of Chemistry, Chonnam National University , Gwangju 500-757, Republic of Korea.

Abstract

A trifluoroethylation of alkynes through a palladium-catalyzed decarboxylative coupling reaction was developed. When alkynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(η(3)-allyl)Cl]2/XantPhos and Cs2CO3 in N,N-dimethylformamide (DMF) at 80 °C for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group tolerance.

PMID:
24628537
DOI:
10.1021/jo5003032
[Indexed for MEDLINE]
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