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Artif Cells Nanomed Biotechnol. 2015;43(6):361-5. doi: 10.3109/21691401.2014.893521. Epub 2014 Mar 14.

Study on clinical application of nano-hydroxyapatite bone in bone defect repair.

Zhu W1,2,3,4, Wang D1,2, Xiong J1,2, Liu J3,4, You W3,4, Huang J3,4, Duan L3,4, Chen J3,4, Zeng Y5.

Author information

1
a Department of Surgery , Guangzhou Medical University , Guangzhou , P. R. China.
2
b Department of Sports medicine , Shenzhen Second People's Hospital (First Affiliated Hospital of Shenzhen University) , Shenzhen, Guangdong , P. R. China.
3
c Shenzhen Tissue Engineering Laboratory , Shenzhen , P. R. China.
4
d Shenzhen Digital Orthopaedic Engineering Laboratory , Shenzhen , P. R. China.
5
e Biomechanics Department, Biomechanics and Medical Information Institute , Beijing University of Technology , Beijing , P. R. China.

Abstract

OBJECTIVE:

To study the clinical effect of bone defect treated with nano-hydroxyapatite(Nano-HA) artificial bone.

METHODS:

From September 2009 to June 2012, 27 cases of bone defect were analyzed retrospectively. The position of bone defect included humerus, radius, ulna, femur, tibia and calcaneus. The range of bone defect was from 0.3 × 1.0 cm to 3 × 6.5 cm. Among them, there were 22 cases with fractures and 5 cases with tumors. All patients were treated with Nano-HA artificial bone. The ability of bone defect repair was evaluated by X-ray exams performed preoperatively and postoperatively. HSS scores were adopted for final evaluation at the latest follow-up.

RESULTS:

The patients were followed up from 11 to 26 months (average of 18.5 months). No general side effects occurred. X-ray photo showed an integrity interface between Nano-HA and bone. Primary healing was obtained in all cases without any complication.

CONCLUSION:

The Nano-HA artificial bone had a good biocompatibility and could be an ideal artificial bone in the reconstruction of bone defect.

KEYWORDS:

artificial bone; bone defect; hydroxyapatite; nano-material

PMID:
24628385
DOI:
10.3109/21691401.2014.893521
[Indexed for MEDLINE]
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