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Korean J Pathol. 2014 Feb;48(1):50-3. doi: 10.4132/KoreanJPathol.2014.48.1.50. Epub 2014 Feb 25.

Large cell calcifying sertoli cell tumor of the testis: a case study and review of the literature.

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Department of Pathology, The Armed Forces Capital Hospital, Seongnam, Korea.
Department of Urology, The Armed Forces Capital Hospital, Seongnam, Korea.
Department of Internal Medicine, The Armed Forces Capital Hospital, Seongnam, Korea.
Department of Pathology and Human Genome Research Institute, Green Cross Reference Laboratory, Yongin, Korea.
Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Korea.


A 24-year-old man was admitted due to an incidentally detected mass in his left testis, which showed radiopaque calcification on plain X-ray film. Left orchiectomy was performed, and the resected testis contained a well-demarcated, hard mass measuring 1.1 cm. Histological analysis revealed that the tumor was composed of neoplastic cells, fibrotic stroma, and laminated or irregularly shaped calcific bodies. The individual cells had abundant eosinophilic or clear cytoplasm with round nuclei, each of which contained one or two conspicuous nucleoli. They were arranged in cords, trabeculae, clusters, and diffuse sheets. There were several foci of intra-tubular growth patterns, with thickening of the basal lamina. Immunohistochemically, the neoplastic cells were positive for S-100 protein and vimentin, focally positive for inhibin alpha, and negative for cytokeratin, CD10, and Melan-A. In addition to reporting this rare case, we also review the relevant literature regarding large cell calcifying Sertoli cell tumors.


Immunohistochemistry; Sertoli cell tumor; Testis

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