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Mol Biol Cell. 2014 Mar;25(6):737-8. doi: 10.1091/mbc.E13-12-0754.

Intrinsic activity in cells and the brain.

Author information

1
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, United Kingdom.

Abstract

Motile cells such as bacteria, amoebae, and fibroblasts display a continual level of energy-consuming reactions involving the cytoskeleton and signal pathways, regardless of whether or not they are actually migrating. I draw parallels between these "silent signals" and the intrinsic activity of the human brain, especially that associated with the brain stem. In both cases, it can be argued that the organism continually rehearses possible future actions, so it can act quickly and accurately when suitable cues are received from the environment.

PMID:
24626850
PMCID:
PMC3952844
DOI:
10.1091/mbc.E13-12-0754
[Indexed for MEDLINE]
Free PMC Article

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