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An Bras Dermatol. 2014 Jan-Feb;89(1):184-6. doi: 10.1590/abd1806-4841.20142197.

Distal and lateral toenail onychomycosis caused by Trichophyton rubrum: treatment with photodynamic therapy based on methylene blue dye.

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Montes Claros State University, Clemente Faria University Hospital, Center for Infectious Diseases Research, Department of Clinical Medicine, Montes ClarosMG, Brazil, Master in Health Sciences - Professor of Dermatology and Research Professor, Department of Clinical Medicine, Center for Infectious Diseases Research - Clemente Faria University Hospital - Montes Claros State University (HUCF - UNIMONTES) - Montes Claros (MG), Brazil.
Montes Claros State University, Montes ClarosMG, Brazil, Specialist, student in the Postgraduate Program in Health Sciences and Designated Professor - Montes Claros State University (UNIMONTES) - Montes Claros (MG), Brazil.
Montes Claros State University, Health Sciences Postgraduate Program, Montes ClarosMG, Brazil, Post-Doctorate in Parasitology - Professor in the Health Sciences Postgraduate Program of the Montes Claros State University (UNIMONTES) - Montes Claros (MG), Brazil.


The study showed the effectiveness of photodynamic therapy based on methylene blue to treat severe distal and lateral subungual toenail onychomycosis. 22 patients were divided into two groups: group A consisting of 11 patients with severe toenail onychomycosis and group B consisting of 11 patients with mild-to-moderate toenail onychomycosis. All patients had onychomycosis caused by Trichophyton rubrum. The patients were treated with sessions of 2% methylene blue aqueous solution irradiated with light emission diode device with 630 nm and 36 J/cm2 biweekly for six months. The clinical response was significantly better in patients with mild-to-moderate (100%) onychomycosis compared with patients with severe onychomycosis (63.6%).

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